Endocrine Abstracts

Introduction: Systemic sclerosis (SSc) is a connective tissue disorder with higher prevalence in females which is characterized by vascular damage, pulmonary hypertension, inflammation and progressive fibrosis of skin and other internal organs such as lung. In the skin it has been shown that dermal adipose tissue atrophy and microangiopathy drive fibrosis development, however which is the underlying mechanism and whether this mechanism is responsible for the female prevalence ...

Objective: Type 2 diabetes mellitus (T2DM) patients have a higher risk for bone fractures, especially in the elderly. However, bone mineral density (BMD) does not reflect their increased bone fragility, potentially based on disturbed bone metabolism or quality. MicroRNAs are promising new biomarkers for fracture risk detection. This study aimed to find specific miRNAs in a large cohort of elderly patients with and without T2DM at risk for osteoporotic fractures.<p class="a...